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KMID : 0376319930050010179
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Dental Journal of CNU
1993 Volume.5 No. 1 p.179 ~ p.197
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A STUDY ON THE REGENERATIVE CAPACITY OF ENDOCHONDRAL AND MEMBRANOUS DEMINERALIZED ALLOGENIC BONE MATRIX GRAFT IN RABBIT
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Jeong Jong-Cheoll
Ryu Sun-Youl
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Abstract
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This study was done to examine the effect of demineralized allogenic bone matrix graft of membranous and endochondral origin compared with autogenous bone chips on healing response in rabbit skull defects.
Four calvarial defects were made and demineralized allogenic bone matrix powder of membranous and endochondral origin and autogenous bone chips were implanted in each of three defects and leaving the fourth defect empty for control.
Undifferentiated mesenchymal cells appeared in autogenous bone and both demineralized allogenic bone graft groups, but inflammatory cell infiltration appeared in control group at 1 week after graft. Two weeks after graft, new bone formation appeared in all grafted area expect control defect and the most active bone formation was observed in autogenous bone graft group and the least appeared in demineralized allogenic bone of membranous origin. Bone formation was not seen in central defect area of control group at 2 weeks after graft. Four weeks after graft, profuse bone formation appeared in entire surface of autogenous bone grafted area and trabecular foramtion appeared in both demineralized allogenic bone graft group, but the degree of trabeculation was smaller in membranous origin than in endochondral origin. Active bone formation was observed in control defect at 4 weeks after graft. Six weeks after graft, mature bone formation was seen at grafted area except control group. In control defect, trabecular formation was seen at the central defect area but outer and inner cortical bone formation was not completed at this time. Complete trabecular formation was observed in all experimental groups at 8 weeks after graft.
Above results suggest that bone regeneration was improved by osteoinductive capacity of demineralized allogenic bone matrix and embryonic origin showed minor effect on the initial regenerative bone formation and bone marrow development.
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